Alterations of proteoglycan synthesis in rabbit articular cartilage induced by intra-articular injection of papain
نویسندگان
چکیده
منابع مشابه
Intra-articular injection of Torin 1 reduces degeneration of articular cartilage in a rabbit osteoarthritis model
OBJECTIVES Recent studies have shown that systemic injection of rapamycin can prevent the development of osteoarthritis (OA)-like changes in human chondrocytes and reduce the severity of experimental OA. However, the systemic injection of rapamycin leads to many side effects. The purpose of this study was to determine the effects of intra-articular injection of Torin 1, which as a specific inhi...
متن کاملThermoanalytical and histological study of intra-articular papain-induced degradation and repair of rabbit cartilage. II. Mature animals.
The effect of papain treatment on the cartilage tissue of the knee joint of mature rabbits was studied by histological and thermoanalytical methods. Changes taking place in the composition of cartilage in the course of ageing were shown. As a result of papain treatment a significant irreversible destruction of the ground substance took place. Papain-induced loss of proteoglycans and the intensi...
متن کاملLocal intra-articular injection of rapamycin delays articular cartilage degeneration in a murine model of osteoarthritis
INTRODUCTION Recent studies have revealed that rapamycin activates autophagy in human chondrocytes preventing the development of osteoarthritis (OA) like changes in vitro, while the systemic injection of rapamycin reduces the severity of experimental osteoarthritis in a murine model of OA in vivo. Since the systemic use of rapamycin is associated with numerous side effects, the goal of the curr...
متن کاملIntra-articular injection of ketorolac in the rat knee joint: effect on articular cartilage and synovium.
We have investigated the effects of intra-articular (i.a.) administration of ketorolac in the rat knee joint. Thirty Sprague-Dawley rats were given 0.25 ml of a standard preparation of ketorolac trometamol (10 mg ml-1) by injection into the right knee joint and 0.25 ml of 0.9% physiological saline solution by injection into the left knee as a control. Ten rats were killed at 24 h, 10 at 48 h an...
متن کاملTreatment of arthritis by intra-articular injection.
In a previous paper (1948) a clinic for the treatment of osteoarthritis was described and certain conclusions were drawn. The technique used was that described by Waugh (1939). The value of this method of intra-articular injection was considered proven but the value of acid solutions not proven. It was felt that the success was due to varying combinations of three factors. Firstly, the injectio...
متن کاملذخیره در منابع من
با ذخیره ی این منبع در منابع من، دسترسی به آن را برای استفاده های بعدی آسان تر کنید
ژورنال
عنوان ژورنال: Osteoarthritis and Cartilage
سال: 1993
ISSN: 1063-4584
DOI: 10.1016/s1063-4584(05)80331-0